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Naked-Eye Biosensing using Plasmonic Nanoparticles

Since the introduction of LSPR as a transduction technique, monitoring the antibody/antigen is only possible by UV-Visible spectroscopy. Indeed, the color changes resulting from a displacement of the LSPR band during target recognition are, for spherical gold nanoparticles that often absorb around 520 nm, a few nanometers and are therefore not visible to the naked eye. Indeed, in this region of the electromagnetic spectrum, red extends over several tens of nm. A plasmon band located slightly lower in the electromagnetic spectrum would generate a much more noticeable colour change for an equivalent displacement. The combination of gold and silver in the form of an alloy or core-shell allows the position of the LSPR band to be modulated and located in the area of interest.

08/11/19

Traductions :
      • Title story on the front page of Biosensors

        Our review on gold nanorods title story on the front page of Biosensors
        https://www.linkedin.com/feed/update/urn:li:activity:6732242466830917632/

      • Article in Nanomaterials

        Our work " Nanostructured and Spiky Gold Shell Growth on Magnetic Particles for SERS Applications ", is now published in Nanomaterials

        link: https://doi.org/10.3390/nano10112136

      • Literature review on Gold Nanorods in Biosensors

        Check our up-to-date overview of gold nanorods in LSPR biosensing. We start from synthesis and coating with a silica shell of controlled thickness and porosity, then, we discuss surface functionalization to attach various bioreceptors and finally, we review AuNR-based LSPR biosensors and their analytical performances.